Diseases > Ticks > Human Granulocytic Ehrlichiosis

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E-71-W
"Ticks - Biology and their control"

E-243-W
"The Biology and Medical Importance of Ticks in Indiana"

E-244-W
"Lyme Disease"

 

Related Links

Purdue Cooperative Extension Service

Centers for Disease Control and Prevention

Indiana State Department of Health

Minnesota Department of Health

Mayo Clinic

Human Granulocytic Ehrlichiosis
Human granulocytic ehrlichiosis (HGE) was recognized as a human disease in Missouri in 1999. Additional cases in the U.S. have been reported in patients with a weak immune system. The parasite previously was known only as a cause of disease in dogs and other canines.
Causative agent
  • A bacterium with the scientific name Ehrlichia ewingii.
  • It is an intracellular parasite that undergoes development within white blood cells, especially granulocytes.
Geographical distribution of cases
  • Documented cases have occurred in Missouri and the southern U.S.
Symptoms of infection
  • Fever, headache, joint pain, and muscle ache.
  • Infections usually are mild, but severe cases can result in death in susceptible humans.
Reservoir hosts of Ehrlichia ewingii
  • Coyotes, other wild canines, and dogs.
Vectors of Ehrlichia ewingii
  • Amblyomma americanum, lone star tick.
  • Rhipicephalus sanguineus, brown dog tick.
Modes of transmission
  • From infected ticks (nymphs and adults) to humans via their bite.
  • From infected tick larvae to nymphs to adults via transstadial transmission.
  • NOTE: there is no human-to-human transmission.
Diagnosis of infection
  • Symptoms, together with onset in late spring into summer.
Treatment of infection
  • Antibiotic prescribed by a physician.
Prevention of infection