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Video Assisted Scientific Articles (VASA)
Available in English
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Disponible en Español
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Our research is focused on the genomic and proteomic response of insects to xenobiotics, such as pesticides or host plant resistance compounds. We work with several insect species, including Drosophila, cowpea bruchids, lice, and termites. Many of these projects are run in collaboration with other programs in the department, on campus, nationally, and internationally.
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Profiling of abundant proteins associated with dichlorodiphenyltrichloroethane resistance in Drosophila melanogaster
Joao H. F. Pedra, Reginaldo A. Festucci-Buselli, Weilin Sun, William M. Muir, Michael E. Scharf, and Barry R. Pittendrigh
One major area of interest for our laboratory is the molecular basis of metabolic pesticide resistance in insects. Although we are working with several pest species, much of our recent research has focused on metabolic resistance to DDT in Drosophila melanogaster . Metabolic resistance to DDT in Drosophila is associated with over-expression of multiple genes with divergent functions, including multiple cytochrome P450s. Proteomic profiling of DDT resistance and susceptible strains also demonstrated differences in expression of proteins associated with increased metabolism in the resistant strains.
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Caste- and development-associated gene expression
in a lower termite
Michael E. Scharf, Dancia Wu-Scharf, Barry R. Pittendrigh and
Gary W. Bennett
Social insects such as termites express dramatic polyphenism (the occurrence of multiple forms in a species on the basis of differential gene expression) both in association with caste differentiation and between castes after differentiation. We have used cDNA macroarrays to compare gene expression between polyphenic castes and intermediary developmental stages of the termite Reticulitermes flavipes.
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