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An Allele

Technical Definition of an Allele - Alternative form of a genetic locus; a single allele for each locus is inherited from each parent (e.g., at a locus for eye color the allele might result in blue or brown eyes).

G.A.M.E. Explanation of an Allele

Let's think about a gene as being like a page in a book. On this imaginary page are the complete instructions to make a product. Let's also imagine that all individuals of a species have this page in their 'genetic library' (genome). From one individual to the next there may be slight differences in the letters that are on this given page. Let's say, for example, there are 99 letters on the page. All of these letters may be the same from one individual's page to the next. But, there may be one, or a few letters, on the page that may be different from one individual to the next. This variation is called an allele.

If the pages have slightly different letters, but they have the same position in the books from one library to the next (in the same species), then these pages are called alleles. Thus, if two people have pages that are exactly alike they both have the same allele. If there is a slight difference in the page that two individuals, have then they have different alleles. These slight changes in the page may or may not influence what is finally manufactured from the instructions on the page. In some cases these differences can have a big effect on an organism. For example, alleles can influence the color of a rabbit's hair (see below) or the color of a flower.

Hypothetical Example

Rabbits typically have two copies of the same pages (genes) in their library. Organisms that typically have two copies of the same page in their library are called diploid organisms. Such (diploid) organisms can have exact same copies of the same page (gene) or two slightly different copies of the same page.

When an individual has two copies of the page (two copies of the same allele) we call these organisms homozygous (homo = meaning the same). When an individual has two copies of slightly different pages then we call these individuals heterozygous (hetero = meaning different). Please see below for an explanation of how alleles can interact. In the below example we use the color of rabbits' fur to further explain alleles.

The two below rabbits have the exact same pair of pages (allele) for hair color. All the letters for the page (gene) controlling hair color are the same between two rabbits. Thus, we would say that they have the same alleles.

Black rabbit
Black rabbit
Each page is analogous to a gene controlling fur color. All the pages are the same allele.
Each page is analogous to a gene controlling fur color. All the pages are the same allele.

If there is even on letter difference between the letters on the two pages, then we have different alleles of the same page (gene). In the example given in the figures immediately below this letter difference on the page causes the rabbits to have a different fur color.

Black rabbit
Spotted rabbit
Each rabbit has two copies of the same page making them homozygous for that page. The pages that the black rabbit has are different from the white rabbit. Thus, they have different alleles.
Each rabbit has two copies of the same page making them homozygous for that page. The pages that the black rabbit has are different from the white rabbit. Thus, they have different alleles.

If you wish to explore alleles further, please click here.

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